[{"data":1,"prerenderedAt":233},["ShallowReactive",2],{"ingredient-gold-sodium-thiosulfate":3},{"id":4,"title":5,"body":6,"category":187,"commonProducts":188,"description":192,"extension":193,"icon":194,"inciName":5,"irritantReason":195,"isCommonIrritant":196,"keyFacts":197,"localNames":207,"meta":209,"navigation":210,"path":211,"relatedArticles":212,"seo":219,"severity":220,"slug":221,"stem":222,"subtitle":223,"symptoms":224,"synonyms":229,"__hash__":232},"ingredients/learn/ingredients/gold-sodium-thiosulfate.md","Gold Sodium Thiosulfate",{"type":7,"value":8,"toc":177},"minimark",[9,14,25,28,31,35,38,41,69,73,99,103,106,125,128,132,135,138,141,145],[10,11,13],"h2",{"id":12},"what-is-gold-sodium-thiosulfate","What is Gold Sodium Thiosulfate?",[15,16,17,20,21,24],"p",{},[18,19,5],"strong",{}," (INCI: Gold Sodium Thiosulfate; chemical name: Sodium aurothiosulfate; also called gold thiosulfate) is a water-soluble gold salt used as the standardized ",[18,22,23],{},"patch test antigen"," for diagnosing gold contact allergy. Gold sodium thiosulfate does not appear in consumer cosmetics or jewelry — its clinical relevance is as a diagnostic agent that identifies whether a patient's immune system is sensitized to gold.",[15,26,27],{},"Gold itself — the metal — is the actual allergen of clinical interest. Gold is an element (atomic number 79) used in jewelry, dental restorations, some medical devices, and occasionally in luxury cosmetics as a decorative or claimed-bioactive ingredient.",[15,29,30],{},"Gold allergy is one of the more commonly identified metal allergies in contact dermatitis clinics. Studies using gold sodium thiosulfate in patch test panels have found positive rates of 8–15% in some patch-tested populations — in some series, higher than nickel allergy rates. However, clinical relevance can be difficult to establish because gold jewelry reactions may take longer to develop than reactions to other metals.",[10,32,34],{"id":33},"why-does-gold-cause-reactions","Why does Gold cause reactions?",[15,36,37],{},"Gold is chemically noble and relatively insoluble, but it can be slowly dissolved by sweat and body fluids into ionic form (Au+ and Au3+). These gold ions can then react with skin proteins to form hapten-protein conjugates, initiating Type IV delayed hypersensitivity sensitization.",[15,39,40],{},"Key aspects of gold allergy:",[42,43,44,51,57,63],"ul",{},[45,46,47,50],"li",{},[18,48,49],{},"Karat and purity",": 24-karat (pure) gold is the least reactive. Lower-karat gold (9K, 14K, 18K) contains significant amounts of other metals — nickel, copper, silver, palladium — some of which are themselves strong sensitizers. A reaction to \"gold\" jewelry may actually represent nickel allergy from the alloy",[45,52,53,56],{},[18,54,55],{},"Surface area and duration",": Earrings (continuous earring wear), necklaces, and rings that are worn continuously provide higher gold ion exposure than occasionally worn items",[45,58,59,62],{},[18,60,61],{},"Dental gold",": Gold alloys in dental restorations can cause oral mucosal reactions in sensitized individuals",[45,64,65,68],{},[18,66,67],{},"Cosmetic gold",": Some luxury skincare products and eye shadows use gold particles as decorative or claimed-bioactive ingredients",[10,70,72],{"id":71},"where-is-gold-found-in-products","Where is Gold found in products?",[42,74,75,81,87,93],{},[45,76,77,80],{},[18,78,79],{},"Jewelry",": Earrings, necklaces, rings, bracelets in 9K to 24K gold",[45,82,83,86],{},[18,84,85],{},"Gold-plated items",": Watch cases, fashion jewelry (gold plating over base metal)",[45,88,89,92],{},[18,90,91],{},"Dental restorations",": Gold crowns, bridges, fillings (less common now with ceramic alternatives)",[45,94,95,98],{},[18,96,97],{},"Luxury cosmetics",": Gold-containing face masks, serums, and highlighters marketed for \"gold glow\"",[10,100,102],{"id":101},"how-to-spot-gold-on-labels","How to spot Gold on labels",[15,104,105],{},"In cosmetics:",[42,107,108,114,120],{},[45,109,110,113],{},[18,111,112],{},"Gold"," — for metallic gold particles",[45,115,116,119],{},[18,117,118],{},"Colloidal Gold"," — nanoparticle gold in solution",[45,121,122,124],{},[18,123,5],{}," — not in consumer products; only in patch test diagnostic kits",[15,126,127],{},"In jewelry: look for hallmark stamps indicating karat (9K, 14K, 18K, 24K) and country of origin.",[10,129,131],{"id":130},"in-indian-products","In Indian products 🇮🇳",[15,133,134],{},"Gold is of profound cultural significance in India — gold jewelry is worn daily by a large percentage of the Indian population, and gold gifting at weddings, festivals, and births is standard practice. India is one of the world's largest gold jewelry markets. The prevalence of daily gold earring and necklace wear means that gold contact allergy is clinically relevant across the Indian population.",[15,136,137],{},"Gold jewelry in India ranges from 22K–24K traditional jewelry (low alloy content) to 14K–18K modern jewelry with higher alloy content. Indian women who develop earlobe dermatitis from gold earrings should not assume the reaction is to the gold itself — testing for nickel (in the alloy) and gold separately is important to identify the actual allergen.",[15,139,140],{},"Luxury \"24K gold facial\" treatments popular at Indian salons use gold foil or gold solution on facial skin — these are potential sensitization opportunities for patients with gold allergy.",[10,142,144],{"id":143},"safer-alternatives","Safer alternatives",[42,146,147,153,159,165,171],{},[45,148,149,152],{},[18,150,151],{},"Platinum or palladium jewelry",": For truly gold-allergic patients, platinum is usually well-tolerated",[45,154,155,158],{},[18,156,157],{},"Surgical stainless steel earrings",": For earlobe reactions, high-quality stainless steel (316L grade) contains minimal nickel release",[45,160,161,164],{},[18,162,163],{},"Titanium jewelry",": Biocompatible, hypoallergenic option without gold or nickel",[45,166,167,170],{},[18,168,169],{},"High-karat (22K–24K) pure gold",": Lower alloy content reduces risk if the reaction is to alloy metals rather than gold itself — test with a new pure gold piece under medical guidance",[45,172,173,176],{},[18,174,175],{},"Gold-free luxury cosmetics",": Avoid gold-particle skincare if gold allergy is confirmed",{"title":178,"searchDepth":179,"depth":179,"links":180},"",2,[181,182,183,184,185,186],{"id":12,"depth":179,"text":13},{"id":33,"depth":179,"text":34},{"id":71,"depth":179,"text":72},{"id":101,"depth":179,"text":102},{"id":130,"depth":179,"text":131},{"id":143,"depth":179,"text":144},"metal",[79,189,190,191],"Dental fillings","Some cosmetics","Gold-plated watches","Gold sodium thiosulfate is used as a patch test marker for gold allergy. Gold allergy is one of the most common metal allergies globally, often presenting as dermatitis from jewelry.","md","⚙️",null,false,[198,201,204],{"label":199,"value":200},"Prevalence","Gold allergy affects approximately 8–15% of patch-tested patients in some series — more common than nickel allergy in certain populations",{"label":202,"value":203},"Purity matters","Lower-karat gold (9K, 14K) contains more alloy metals (nickel, copper) that may be the actual sensitizers; 24K pure gold rarely causes reactions",{"label":205,"value":206},"ACDS standard","Gold sodium thiosulfate (0.5% in petrolatum) is the standard patch test agent for gold allergy",[208],"सोना एलर्जी",{},true,"/learn/ingredients/gold-sodium-thiosulfate",[213,216],{"slug":214,"title":215},"/learn/patch-test-shopping-guide","Patch Test Shopping Guide",{"slug":217,"title":218},"/learn/patch-test-results-now-what","Patch Test Results: Now What?",{"title":5,"description":192},"moderate","gold-sodium-thiosulfate","learn/ingredients/gold-sodium-thiosulfate","The patch test marker for gold allergy — relevant for jewelry and some cosmetics",[225,226,227,228],"Contact dermatitis at jewelry contact sites (ears, neck, wrist)","Earlobe dermatitis from gold earrings","Dermatitis around gold dental restorations (rare)","Facial dermatitis from gold-containing cosmetics",[112,230,231],"Gold allergy","Sodium aurothiosulfate","mvr9JF_fVnHyoQ5AhdNV1tUr5a-r5T6RH9sgPyiTba8",1778416676648]