[{"data":1,"prerenderedAt":196},["ShallowReactive",2],{"ingredient-hydrocortisone-17-butyrate":3},{"id":4,"title":5,"body":6,"category":156,"commonProducts":157,"description":160,"extension":161,"icon":162,"inciName":92,"irritantReason":163,"isCommonIrritant":164,"keyFacts":165,"localNames":175,"meta":176,"navigation":177,"path":178,"relatedArticles":179,"seo":183,"severity":184,"slug":185,"stem":186,"subtitle":187,"symptoms":188,"synonyms":193,"__hash__":195},"ingredients/learn/ingredients/hydrocortisone-17-butyrate.md","Hydrocortisone-17-Butyrate",{"type":7,"value":8,"toc":146},"minimark",[9,14,25,28,35,39,42,45,58,62,76,79,83,86,106,110,113,116,120],[10,11,13],"h2",{"id":12},"what-is-hydrocortisone-17-butyrate","What is Hydrocortisone-17-Butyrate?",[15,16,17,20,21,24],"p",{},[18,19,5],"strong",{}," (INCI: Hydrocortisone Butyrate; brand name: Locoid) is a butyrate ester of hydrocortisone formed by esterification at the C-17 position. Despite sharing the \"hydrocortisone\" name with plain hydrocortisone (Group A), the butyrate esterification fundamentally changes its chemical character — placing it in ",[18,22,23],{},"Group B (acetonide and butyrate class)"," of the corticosteroid contact allergen classification.",[15,26,27],{},"This classification distinction matters greatly clinically: a patient with Group A allergy (to plain hydrocortisone) can usually tolerate hydrocortisone-17-butyrate, and vice versa. The cross-reaction pattern is within classes, not between them.",[15,29,30,31,34],{},"In the context of patch testing, hydrocortisone-17-butyrate is used alongside ",[18,32,33],{},"budesonide"," to more completely screen for Group B steroid allergy. Its inclusion in the patch test panel increases detection sensitivity for the Group B class.",[10,36,38],{"id":37},"why-does-hydrocortisone-17-butyrate-cause-reactions","Why does Hydrocortisone-17-Butyrate cause reactions?",[15,40,41],{},"The mechanism is the same as for other corticosteroid contact allergens: modified Type IV delayed hypersensitivity where the molecule or its metabolites form hapten-protein conjugates. The steroid's anti-inflammatory properties partially mask the allergic reaction, leading to the characteristic pattern of incomplete treatment response.",[15,43,44],{},"Hydrocortisone-17-butyrate allergy is more likely in patients who:",[46,47,48,52,55],"ul",{},[49,50,51],"li",{},"Have used moderately or highly potent topical steroids for extended periods",[49,53,54],{},"Have chronic, treatment-resistant eczema (raising suspicion that steroid allergy is maintaining the condition)",[49,56,57],{},"Have concurrent reactions to budesonide on patch testing (co-sensitization within Group B is common)",[10,59,61],{"id":60},"where-is-hydrocortisone-17-butyrate-found-in-products","Where is Hydrocortisone-17-Butyrate found in products?",[46,63,64,70],{},[49,65,66,69],{},[18,67,68],{},"Locoid cream and ointment",": The primary product form, used for eczema, psoriasis, and contact dermatitis",[49,71,72,75],{},[18,73,74],{},"Generic hydrocortisone butyrate formulations",": Available by prescription in some markets",[15,77,78],{},"In India, Locoid cream may be available through import or prescription channels; generic hydrocortisone butyrate preparations may also be compounded at dermatology clinics.",[10,80,82],{"id":81},"how-to-spot-hydrocortisone-17-butyrate-on-labels","How to spot Hydrocortisone-17-Butyrate on labels",[15,84,85],{},"On pharmaceutical labels:",[46,87,88,94,100],{},[49,89,90,93],{},[18,91,92],{},"Hydrocortisone Butyrate"," — the generic INN",[49,95,96,99],{},[18,97,98],{},"Hydrocortisone 17-Butyrate"," — full chemical descriptor",[49,101,102,105],{},[18,103,104],{},"Locoid"," — brand name",[10,107,109],{"id":108},"in-indian-products","In Indian products 🇮🇳",[15,111,112],{},"Hydrocortisone butyrate is less commonly used in India compared to other moderately potent steroids like betamethasone valerate or mometasone furoate, which dominate the Indian prescription market. However, dermatologists managing steroid-resistant eczema may encounter it, and its inclusion in corticosteroid allergy patch test panels is important for comprehensive evaluation of Indian patients with suspected steroid contact allergy.",[15,114,115],{},"Given the enormous prevalence of prolonged topical steroid use in India — including inappropriate self-medication with potent steroids — corticosteroid contact allergy as a complication is likely underdiagnosed in Indian clinical settings.",[10,117,119],{"id":118},"safer-alternatives","Safer alternatives",[46,121,122,128,134,140],{},[49,123,124,127],{},[18,125,126],{},"Calcineurin inhibitors",": Tacrolimus and pimecrolimus for eczema management without corticosteroid contact allergy risk",[49,129,130,133],{},[18,131,132],{},"Crisaborole (Eucrisa)",": Phosphodiesterase-4 inhibitor for mild-moderate eczema; non-steroidal",[49,135,136,139],{},[18,137,138],{},"Dupilumab (Dupixent)",": Injectable biologic for moderate-severe eczema; no topical allergen concerns",[49,141,142,145],{},[18,143,144],{},"Confirmed-safe steroid class",": If only Group B allergy, Group A steroids (hydrocortisone, prednisolone) may be used — but must confirm with patch testing first",{"title":147,"searchDepth":148,"depth":148,"links":149},"",2,[150,151,152,153,154,155],{"id":12,"depth":148,"text":13},{"id":37,"depth":148,"text":38},{"id":60,"depth":148,"text":61},{"id":81,"depth":148,"text":82},{"id":108,"depth":148,"text":109},{"id":118,"depth":148,"text":119},"corticosteroid",[158,159],"Eczema cream","Topical steroid","A moderately potent corticosteroid and a patch test marker for Group B corticosteroid allergy. Like budesonide, it can paradoxically cause contact dermatitis in patients being treated for eczema.","md","💉",null,false,[166,169,172],{"label":167,"value":168},"Group B marker","Hydrocortisone-17-butyrate is a confirmatory patch test marker for Group B corticosteroid allergy (acetonide and butyrate class)",{"label":170,"value":171},"Potency","More potent than plain hydrocortisone (Group A) — belongs to potency class II (moderately potent) in the UK steroid potency ranking",{"label":173,"value":174},"Locoid brand","Brand name Locoid (Ferndale Pharma) — contains hydrocortisone 17-butyrate as the active corticosteroid",[],{},true,"/learn/ingredients/hydrocortisone-17-butyrate",[180],{"slug":181,"title":182},"/learn/patch-test-results-now-what","Patch Test Results: Now What?",{"title":5,"description":160},"moderate","hydrocortisone-17-butyrate","learn/ingredients/hydrocortisone-17-butyrate","A butyrate-ester corticosteroid and marker for Group B steroid allergy alongside budesonide",[189,190,191,192],"Paradoxical worsening of eczema with treatment","Contact dermatitis at steroid application sites","Incomplete or absent response to steroid therapy","Skin atrophy masking underlying allergy",[104,194],"Hydrocortisone 17-butyrate","eQFigaYT9bL5jNO-RoCq5T7vzh1pvpZzu8n27kQschk",1778416676560]