[{"data":1,"prerenderedAt":202},["ShallowReactive",2],{"ingredient-lyral":3},{"id":4,"title":5,"body":6,"category":158,"commonProducts":159,"description":163,"extension":164,"icon":165,"inciName":98,"irritantReason":166,"isCommonIrritant":167,"keyFacts":168,"localNames":178,"meta":179,"navigation":167,"path":180,"relatedArticles":181,"seo":188,"severity":189,"slug":190,"stem":191,"subtitle":192,"symptoms":193,"synonyms":198,"__hash__":201},"ingredients/learn/ingredients/lyral.md","Lyral",{"type":7,"value":8,"toc":148},"minimark",[9,14,25,32,35,39,42,45,58,61,65,68,88,92,111,114,118,121,124,128],[10,11,13],"h2",{"id":12},"what-is-lyral","What is Lyral?",[15,16,17,20,21,24],"p",{},[18,19,5],"strong",{}," (INCI: Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde; abbreviation: HICC; chemical name: 4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde) is a synthetic fragrance chemical created in the 1970s to provide a ",[18,22,23],{},"muguet (lily of the valley), clean floral"," scent. For decades it was one of the most widely used synthetic fragrance ingredients globally, appearing in hundreds of perfumes, skincare products, soaps, and household products.",[15,26,27,28,31],{},"Lyral was identified as a significant contact allergen in the 1990s and increasingly so through the 2000s. Its prevalence in cosmetics, combined with its sensitizing potency, led to extremely high patch test positivity rates in contact dermatitis clinics — estimated at 2–3% in the general European population and considerably higher among dermatitis patients. This led the European Scientific Committee on Consumer Safety to recommend its restriction, and eventually to a ",[18,29,30],{},"complete ban from EU cosmetics in 2019"," (Regulation 2017/1410).",[15,33,34],{},"The ban applies to products sold in the EU. Products manufactured outside the EU, including those that may be imported into India through various channels, may still contain lyral.",[10,36,38],{"id":37},"why-does-lyral-cause-reactions","Why does Lyral cause reactions?",[15,40,41],{},"Lyral (HICC) is an alpha,beta-unsaturated aldehyde, making it a strong electrophile that readily reacts with nucleophilic amino acid residues in skin proteins (particularly lysine and cysteine) to form stable hapten-protein conjugates. These conjugates trigger Type IV delayed hypersensitivity.",[15,43,44],{},"The combination of:",[46,47,48,52,55],"ul",{},[49,50,51],"li",{},"High chemical reactivity (strong hapten formation potential)",[49,53,54],{},"Very widespread presence in cosmetics and household products",[49,56,57],{},"Relatively high exposure doses (concentrated perfumes)",[15,59,60],{},"...made lyral one of the leading causes of fragrance contact allergy in the pre-ban era. Reactions are often severe and persistent, with some patients developing widespread airborne contact dermatitis from exposure to lyral-containing perfumes in their environment even without direct skin contact.",[10,62,64],{"id":63},"where-is-lyral-found-in-products","Where is Lyral found in products?",[15,66,67],{},"Given the EU ban, lyral should no longer be present in EU-compliant products. However, it may still appear in:",[46,69,70,76,82],{},[49,71,72,75],{},[18,73,74],{},"Older fragrance formulations"," manufactured before or outside the EU ban",[49,77,78,81],{},[18,79,80],{},"Non-EU manufactured perfumes and cosmetics"," imported into India and other markets without equivalent restrictions",[49,83,84,87],{},[18,85,86],{},"Some perfumes sold in India"," that are manufactured in countries without equivalent EU restrictions",[10,89,91],{"id":90},"how-to-spot-lyral-on-labels","How to spot Lyral on labels",[46,93,94,100,106],{},[49,95,96,99],{},[18,97,98],{},"Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde"," — INCI name",[49,101,102,105],{},[18,103,104],{},"HICC"," — industry abbreviation",[49,107,108,110],{},[18,109,5],{}," — trade/common name",[15,112,113],{},"On EU products post-2019, it should not appear. On non-EU products, the INCI name \"Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde\" will be listed if declared.",[10,115,117],{"id":116},"in-indian-products","In Indian products 🇮🇳",[15,119,120],{},"India does not currently have an equivalent ban to the EU's 2019 lyral prohibition. This means that perfumes and fragranced cosmetics manufactured in or imported into India from non-EU sources may still contain lyral. This includes some imported colognes, perfumes, and fragranced cosmetics sold through parallel import channels, gray markets, or from countries outside the EU regulatory framework.",[15,122,123],{},"Indian dermatology patients who test positive for HICC/lyral should be aware that the ingredient may still be present in some products available in the Indian market. When purchasing fragrance products in India, EU-manufactured (post-2019) products are the safest option for lyral-sensitive individuals.",[10,125,127],{"id":126},"safer-alternatives","Safer alternatives",[46,129,130,136,142],{},[49,131,132,135],{},[18,133,134],{},"EU-manufactured fragrances post-2019",": Required to be lyral-free under EU regulation",[49,137,138,141],{},[18,139,140],{},"Fragrance-free skincare and personal care",": Eliminates all fragrance allergen exposure",[49,143,144,147],{},[18,145,146],{},"Certified fragrance-free products",": Look for products with IFRA (International Fragrance Association) compliance claims or dermatologist-tested fragrance-free labels",{"title":149,"searchDepth":150,"depth":150,"links":151},"",2,[152,153,154,155,156,157],{"id":12,"depth":150,"text":13},{"id":37,"depth":150,"text":38},{"id":63,"depth":150,"text":64},{"id":90,"depth":150,"text":91},{"id":116,"depth":150,"text":117},{"id":126,"depth":150,"text":127},"fragrance",[160,161,162],"Perfume","Skincare (older formulations)","Soap","A synthetic lily-of-the-valley fragrance that was one of the most common fragrance allergens in Europe before its EU ban in 2019. Still potentially present in non-EU manufactured products sold globally.","md","🌸",null,true,[169,172,175],{"label":170,"value":171},"EU ban","Banned from all EU cosmetics since August 2019 (Regulation 2017/1410) due to high sensitization rates",{"label":173,"value":174},"FM II component","One of the 6 allergens in Fragrance Mix II; its EU ban in 2019 post-dates its inclusion in the FM II test panel",{"label":176,"value":177},"Sensitization rate","Estimated to affect 2–3% of the general European population; one of the most prevalent fragrance allergens identified through patch testing",[],{},"/learn/ingredients/lyral",[182,185],{"slug":183,"title":184},"/learn/patch-test-results-now-what","Patch Test Results: Now What?",{"slug":186,"title":187},"/learn/reading-cosmetic-labels","How to Read Cosmetic Labels",{"title":5,"description":163},"high","lyral","learn/ingredients/lyral","A synthetic muguet fragrance banned in EU cosmetics since 2019 — still present in older products",[194,195,196,197],"Allergic contact dermatitis","Persistent facial and neck dermatitis from perfume use","Airborne contact dermatitis","Eyelid dermatitis from fragranced products",[104,199,200],"Hydroxyisohexyl 3-cyclohexene carboxaldehyde","4-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde","Mleg7vBHpqJLtSMa07g69oylmW5toWpP6cbzBm-TNps",1778416676340]