[{"data":1,"prerenderedAt":210},["ShallowReactive",2],{"ingredient-mixed-dialkyl-thioureas":3},{"id":4,"title":5,"body":6,"category":166,"commonProducts":167,"description":172,"extension":173,"icon":174,"inciName":5,"irritantReason":175,"isCommonIrritant":176,"keyFacts":177,"localNames":187,"meta":188,"navigation":189,"path":190,"relatedArticles":191,"seo":195,"severity":196,"slug":197,"stem":198,"subtitle":199,"symptoms":200,"synonyms":205,"__hash__":209},"ingredients/learn/ingredients/mixed-dialkyl-thioureas.md","Mixed Dialkyl Thioureas",{"type":7,"value":8,"toc":156},"minimark",[9,14,33,36,39,43,46,49,71,75,101,105,116,120,123,126,130],[10,11,13],"h2",{"id":12},"what-is-mixed-dialkyl-thioureas","What is Mixed Dialkyl Thioureas?",[15,16,17,20,21,24,25,28,29,32],"p",{},[18,19,5],"strong",{}," is a patch test mixture containing primarily ",[18,22,23],{},"dibutylthiourea (DBTU)"," and ",[18,26,27],{},"diethylthiourea (DETU)"," — rubber vulcanization accelerators from the thiourea chemical class. These compounds are used in the manufacture of ",[18,30,31],{},"neoprene (polychloroprene) rubber",", which is the material used in wetsuits, knee braces, ankle supports, orthopedic compression garments, some diving gear, and certain types of elastic clothing.",[15,34,35],{},"Unlike thiurams and carbamates that are more associated with natural latex rubber, thioureas are particularly characteristic of neoprene rubber chemistry. This distinction is clinically important: patients with thiourea allergy may tolerate latex gloves but develop dermatitis from neoprene-containing products, and vice versa.",[15,37,38],{},"Mixed dialkyl thioureas are included in ACDS patch test panels as a standard rubber accelerator allergen, particularly relevant for recreational athletes (swimmers, surfers, divers), physical therapy patients using orthopedic supports, and workers in neoprene-manufacturing industries.",[10,40,42],{"id":41},"why-does-mixed-dialkyl-thioureas-cause-reactions","Why does Mixed Dialkyl Thioureas cause reactions?",[15,44,45],{},"Thiourea compounds sensitize through Type IV delayed hypersensitivity. The thiourea functional group (-NH-CS-NH-) is chemically reactive toward skin proteins, forming hapten-protein conjugates that initiate immune sensitization.",[15,47,48],{},"Unique aspects of thiourea sensitization:",[50,51,52,59,65],"ul",{},[53,54,55,58],"li",{},[18,56,57],{},"Wetsuit pattern",": Sensitized divers and surfers present with a distinctive dermatitis pattern corresponding to their wetsuit — torso, upper arms, legs",[53,60,61,64],{},[18,62,63],{},"Orthopedic brace dermatitis",": Patients prescribed knee, ankle, or wrist braces containing neoprene may develop dermatitis specifically in the brace-covered area",[53,66,67,70],{},[18,68,69],{},"Occupational neoprene exposure",": Workers manufacturing neoprene products are at risk for occupational thiourea sensitization",[10,72,74],{"id":73},"where-is-mixed-dialkyl-thioureas-found","Where is Mixed Dialkyl Thioureas found?",[50,76,77,83,89,95],{},[53,78,79,82],{},[18,80,81],{},"Neoprene wetsuits and diving suits",": Primary source for recreational athletes",[53,84,85,88],{},[18,86,87],{},"Orthopedic and athletic supports",": Knee braces, ankle supports, back supports, wrist braces",[53,90,91,94],{},[18,92,93],{},"Compression sportswear",": Some high-performance compression garments use neoprene",[53,96,97,100],{},[18,98,99],{},"Neoprene gloves",": Cold-water fishing or diving gloves",[10,102,104],{"id":103},"how-to-identify-thiourea-exposure","How to identify thiourea exposure",[50,106,107,110,113],{},[53,108,109],{},"Dermatitis distribution corresponding to neoprene-containing equipment",[53,111,112],{},"Improvement when the offending garment or brace is removed",[53,114,115],{},"Patch testing with dibutylthiourea and diethylthiourea antigens",[10,117,119],{"id":118},"in-indian-products","In Indian products 🇮🇳",[15,121,122],{},"Neoprene-containing products in India include imported wetsuits (for coastal water sports), orthopedic braces (widely used for knee and back pain — a major health concern in India), and some sporting goods. Physiotherapy clinics and orthopedic practices in India frequently prescribe neoprene knee and ankle supports for patients with joint pain.",[15,124,125],{},"Indian patients who develop dermatitis under physiotherapy braces or orthopedic supports should consider neoprene/thiourea allergy as a cause, particularly when the rash follows the distribution of the support device.",[10,127,129],{"id":128},"safer-alternatives","Safer alternatives",[50,131,132,138,144,150],{},[53,133,134,137],{},[18,135,136],{},"Neoprene-free braces",": Many orthopedic supports are available in cotton, polyester, or silicone — confirm neoprene-free construction with manufacturer",[53,139,140,143],{},[18,141,142],{},"Silicone-based supports",": Silicone orthopedic supports contain no rubber accelerators",[53,145,146,149],{},[18,147,148],{},"Cotton protective liner",": Wearing a cotton tube sock or sleeve under a neoprene brace can reduce skin contact",[53,151,152,155],{},[18,153,154],{},"Lyocell or cotton-lined wetsuits",": Some wetsuit manufacturers offer skin-friendly linings; \"accelerator-free\" neoprene is also available from specialized manufacturers",{"title":157,"searchDepth":158,"depth":158,"links":159},"",2,[160,161,162,163,164,165],{"id":12,"depth":158,"text":13},{"id":41,"depth":158,"text":42},{"id":73,"depth":158,"text":74},{"id":103,"depth":158,"text":104},{"id":118,"depth":158,"text":119},{"id":128,"depth":158,"text":129},"rubber_accelerator",[168,169,170,171],"Neoprene wetsuit","Elastic clothing","Orthopedic braces","Knee and ankle supports","A class of rubber accelerators used in neoprene wetsuits, elastic clothing, and orthopedic braces. Can cause contact dermatitis at sites covered by neoprene-containing materials.","md","🧤",null,false,[178,181,184],{"label":179,"value":180},"Neoprene-specific","Thiourea accelerators are commonly used in neoprene (polychloroprene) rubber manufacturing — more specifically associated with neoprene than latex",{"label":182,"value":183},"ACDS listing","ACDS-listed rubber accelerator; particularly relevant for swimmers, divers, and users of orthopedic supports",{"label":185,"value":186},"Components","Mix contains dibutylthiourea (DBTU) and diethylthiourea (DETU) as the primary test allergens",[],{},true,"/learn/ingredients/mixed-dialkyl-thioureas",[192],{"slug":193,"title":194},"/learn/patch-test-results-now-what","Patch Test Results: Now What?",{"title":5,"description":172},"moderate","mixed-dialkyl-thioureas","learn/ingredients/mixed-dialkyl-thioureas","Rubber accelerators in neoprene wetsuits and elastic — a cause of immersion suit dermatitis",[201,202,203,204],"Contact dermatitis at neoprene-contact sites","Wetsuit-pattern dermatitis on torso and limbs","Dermatitis under orthopedic braces and supports","Rash from elastic-containing sports compression wear",[206,207,208],"Dialkyl Thiourea","Dibutylthiourea","Diethylthiourea","NW6x-YGE8GcK1y26L0JT6EwLdnEeG7mjy6-tgb0-c6g",1778416676507]